Venue: Recreation Ground Date: Saturday, 5 November Kick-off: 1415 GMT
Coverage: Live on BBC Radio Bristol & live scores on BBC Sport website
Bath name prop David Wilson in their starting side for the first time this season and welcome back Francois Louw from injury in the back row. Dan Hipkiss returns to the centres to partner Matt Carraro.
Harlequins have England scrum-half Danny Care on the bench following his three months out with a toe injury.
In the pack, hooker Joe Gray returns and Maurie Fa'asavalu makes his first league start in the back row this term with Chris Robshaw and Nick Easter.
Bath director of rugby Sir Ian McGeechan told BBC Points West:
No rush on Barkley return - McGeechan"Harlequins didn't lose too many players to the World Cup which helped.
"They've built a good strong momentum and they've got a good all-round game.
"They've won in some difficult places but we want to make it as difficult as possible for them at the Rec on Saturday."
Bath: Abendanon; Woodburn, Hipkiss, Carraro, Biggs; Vesty, Claassens; Catt, Mears, Wilson; Hooper (capt), Attwood; Skirving, Louw, Taylor.
Replacements: Batty, Beech, Perenise, Caldwell, Mercer, Cook, Heathcote, Cuthbert.
Harlequins: Brown; Stegmann, Lowe, Turner-Hall, Smith; Evans, Dickson; Marler, Gray, Johnston; Kohn, Robson; Fa'asavalu, Robshaw (capt), Easter.
Replacements: Brooker, Mayhew, Sickler, Vallejos, Wallace, Care, Clegg, Hopper.
